Conserved sequence blocks in kinetoplast minicircles from diverse species of trypanosomes

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Conserved sequence blocks in kinetoplast minicircles from diverse species of trypanosomes.

Kinetoplast DNA minicircles from various species of trypanosomes are heterogeneous in nucleotide sequence to various degrees but in all instances contain a conserved sequence region of 100 to 200 base pairs present in one, two, or four copies per minicircle. Comparison of the conserved sequence regions of minicircles from eight species of trypanosomes revealed a common sequence motif consisting...

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Kinetoplast DNA minicircles: regions of extensive sequence divergence.

Previous work has shown that the kinetoplast minicircle DNA of Leishmania species exhibits species-specific sequence divergence and this observation has led to the development of a DNA probe-based diagnostic test for leishmaniasis. In the work reported here, we demonstrate that the minicircle is composed of three types of DNA sequences with differing specificities reflecting different rates of ...

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Trypanosoma cruzi: sequence analysis of the variable region of kinetoplast minicircles.

The comparisons of 170 sequences of kinetoplast DNA minicircle hypervariable region obtained from 19 stocks of Trypanosoma cruzi and 2 stocks of Trypanosoma cruzi marenkellei showed that only 56% exhibited a significant homology one with other sequences. These sequences could be grouped into homology classes showing no significant sequence similarity with any other homology group. The 44% remai...

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Olfaction is a vitally important sense for all animals. There are striking similarities between species in the organization of the olfactory pathway, from the nature of the odorant receptor proteins, to perireceptor processes, to the organization of the olfactory CNS, through odor-guided behavior and memory. These common features span a phylogenetically broad array of animals, implying that the...

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Sequences of two kinetoplast DNA minicircles of Tryptanosoma brucei.

Kinetoplast DNA of Trypanosoma brucei is composed of a network of about 10,000 interlocked minicircle DNA molecules (1.0 kilobase) that are catenated with about 50 maxicircle DNA molecules (23 kilobases). Several different DNA . DNA hybridization techniques using individual minicircle DNA sequences cloned in Escherichia coli have indicated that each minicircle molecule contains about one-fourth...

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ژورنال

عنوان ژورنال: Molecular and Cellular Biology

سال: 1989

ISSN: 0270-7306,1098-5549

DOI: 10.1128/mcb.9.3.1365-1367.1989